Calcium channel blockers and mortality in hospitalized pulmonary tuberculosis

Abstract

Background

Calcium channel blockers (CCB) is associated with lower rate of acute respiratory failure in hospitalized patients with pneumonia and mortality in sepsis. However, the association between CCB exposure and mortality in hospitalized patients with intrapulmonary tuberculosis is still scarce. 

Methods

We conducted retrospective cohort study to examine the association between CCB exposure and mortality in hospitalized patients with intrapulmonary tuberculosis by extracting data from their medical records at Khon Kaen Hospital, Thailand from 1 January 2013 to 30 August 2017. Using CCB during admission was our exposure. The primary outcome was 90-day all-cause m ortality. The secondary outcomes were acute respiratory failure (ARF) and duration of ventilation.

Results

  The 90-day all-cause mortality were similar between the former group and non-CCB exposure (56 [35.7%] vs. 969 [36.1%]; relative risk, 0.999; 95% CI, 0.981 to 1.018; P=0.915). In addition, CCB exposure was not associated with lower acute respiratory failure that occurred during hospitalization (42 [26.8%] vs. 712 [26.5%]; relative risk, 1.001; 95% CI, 0.981 to 1.021; P=0.949).We found that age, intubation on admission, initial three-drugs anti-tuberculosis regimen and proton pump inhibitors were associated with higher 90-day all-cause mortality. Whereas, initial treatment with IRZE regimen was associated with lower mortality.

Conclusion

CCB exposure was not associated with 90-day all-cause mortality compared with non-CCB exposure in hospitalized patients with intrapulmonary tuberculosis.